The Spatial Logic of Metabolism: How Cells Organize Enzymes for Efficiency
A new study published in the Proceedings of the National Academy of Sciences investigates the formation of “metabolons”—dynamic, multi-enzyme complexes that channel substrates efficiently through sequential metabolic reactions. Using advanced fluorescence microscopy, the research provides a detailed look at how cells spatially and temporally coordinate organelles and enzymes to optimize metabolic flux and control. The findings reveal the critical factors that drive the assembly of these complexes, offering a clearer picture of a fundamental regulatory mechanism in cellular metabolism that goes beyond simple genetic control.
Why it might matter to you: For a professional focused on cell signaling and regulation, this work directly connects to understanding how metabolic pathways like the PI3K/AKT and mTOR pathways are spatially regulated, which is crucial for processes like cell growth and cancer metabolism. The methodology of live-cell imaging to study dynamic protein complexes provides a powerful framework that could be applied to investigate other key signaling hubs or biomolecular condensates in your research.
Source →Stay curious. Stay informed — with Science Briefing.
Always double check the original article for accuracy.