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Home - Medicine - 靶向肿瘤“燃料库”:温敏纳米凝胶重塑三阴性乳腺癌免疫治疗格局

Medicine

靶向肿瘤“燃料库”:温敏纳米凝胶重塑三阴性乳腺癌免疫治疗格局

Last updated: January 23, 2026 1:14 am
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药理学领域最新发现

一份关于您所在领域最相关研究进展的简明简报,旨在提供清晰且有影响力的信息。

靶向肿瘤“燃料库”:温敏纳米凝胶重塑三阴性乳腺癌免疫治疗格局

一项发表于《分子药剂学》的研究开发了一种靶向CD36受体的温敏性小檗碱纳米凝胶,用于治疗三阴性乳腺癌。该策略旨在阻断癌细胞通过CD36“劫持”脂质作为生长燃料的能力,从而逆转免疫抑制性的肿瘤微环境。研究证实,这种纳米药物与抗PD-L1免疫疗法联用,能显著增强抗肿瘤效果,为攻克这类难治性癌症提供了新的联合治疗方案。

为何与您相关:
这项研究展示了一种通过靶向肿瘤代谢来增强现有疗法效能的先进递送策略。对于专注于提高药物生物利用度和纳米载体体内命运的您而言,它提供了一个将代谢干预与智能递送系统(如温敏纳米凝胶)相结合的范例。这种思路可能启发您探索如何将类似的“阻断供应”策略应用于其他依赖特定营养的疾病,从而拓展纳米药物在口服或透皮递送之外的治疗疆界。


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